Graphene (G) is an atomic-thick sheet of carbon atoms arranged in 2D honeycomb structure with unique physical, chemical and mechanical properties and its isolation in 2004 has earned the two inventors, Drs. Andre Geim and Konstantin Novoselov, the 2010 Nobel Prize in Physics. Recently, the capability of biofunctionalization of graphene and its derivative, graphene oxide (GO), has drawn intense attention for a plethora of applications in biotechnology. In particular, GO has shown tremendous potential in bioapplications including bioimaging, cellular probing, cellular growth and differentiation, gene and drug delivery and photothermal therapy.

In this study, we generate an inject-printed GO nanointerface for cell patterning, and the diameter size of micropatterned GO are in a range of 30 to 80 µm. This GO-patterned substrate could be served as a platform for patterning of retinal pigmented epithelium (RPE) cell. In addition, the proliferation rate and cell viability of RPE cells are well maintained on this micropatterned substrate during culturing. Our work highlights a scalable, cost-effective, general approach to improve the functionalization of inferface between cells and chip, which creates diverse opportunities for next-generation bio-subretinal chip applications.

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